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Computational design of second-site suppressor mutations at protein-protein interfaces
Sammond, D. W., Eletr, Z. M., Purbeck, C. and Kuhlman, B. Proteins 78:1055-1065

Metal templated design of protein interfaces
Salgado, E. N., Ambroggio, X. I., Brodin, J. D., Lewis, R. A., Kuhlman, B. and Tezcan, F. A. Proc Natl Acad Sci U S A 107:1827-1832.

Rosetta.design3.1

computational protein design software

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Rosetta design can be used to identify sequences compatible with a given protein backbone. Some of Rosetta design's successes include the design of a novel protein fold, redesign of an existing protein for greater stability, increased binding affinity between two proteins, and the design of novel enzymes.

If you would like to use Rosetta.design, please register for an account. If you already have an account, you can login below.

- Kuhlman Lab

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Figure 1
 

crystal structure of Top7

Comparison of the computationally designed model (blue) to the solved x-ray structure (red) of Top7 reveals a backbone RMSD of only 1.17A.